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As for the role that caffeine has in the purported benefits of the coffee enema, drinking coffee is a far more effective method for increasing the amount of caffeine in your blood (and hence causing vasodilation to potentially send toxins from the blood into the colon, or causing increased bile acid secretion to potentially facilitate liver detoxification) compared to administering it at the other end

It can also suppress the efflux pump, preventing some transporter proteins from being released by intestinal epithelial cells or enterocytes when membrane-bound (Ways et al., 2018)

Lowering the darkening effect on the skin: Cream can help to lighten the skin and reduce the darkness

Psychiatry 5 , e596e596